Unlocking the Secrets of Lysozyme Interactions! ?✨

Did you know that lysozyme, a powerful enzyme found in tears, saliva, and egg whites, can interact with different molecules in fascinating ways? Our latest research explores lysozyme’s binding behavior with:

• Chlorhexidine (CHX)– A key antimicrobial agent binds to lysozyme with impressive precision, helping us optimize CHX-based oral care products.  https://doi.org/10.1002/slct.202405476
• β-Sitosterol– A plant-based compound (found in nuts and seeds) shows strong binding with lysozyme, offering insights for nutrition and pharmaceutical advancements!  https://doi.org/10.1002/cbdv.202401470
• Tannic Acid– Common in wine and tea , tannic acid interacts with lysozyme, influencing food flavors and digestion! https://doi.org/10.1002/fsn3.4315
• Endocrine Disruptors– Harmful chemicals like Diethylhexyl phthalate (DEHP) & Mono(2-ethylhexyl) phthalate (MEHP), known for their toxic effects on human health, were found to bind to lysozyme! DEHP, in particular, displayed a significantly stronger binding affinity, which may have important implications for immune function and toxicology. ☣️https://doi.org/10.1016/j.toxlet.2025.04.005

Using cutting-edge techniques like surface plasmon resonance, molecular docking, and molecular dynamics simulations, we are unveiling the hidden world of these molecular interactions.

Our findings could impact oral care, drug development, toxicology, and food science!?

Stay tuned for more exciting discoveries! #Biochemistry #MolecularMagic #LysozymeScience #docking #moleculardynamics

 

Ahbab, M. A., Taşteki̇l, I., Pınar, E. G., Özbek, P., & Türkoğlu, E. A. (2025). Multi-approach study on diethylhexyl phthalate and monoethylhexyl phthalate binding to lysozyme: In silico, bioactivity and surface plasmon resonance analyses. Toxicology Letters, 408, 54-64.

Çungur, S., Taştekil, I., Ozbek, P., & Türkoğlu, E. A. (2025). Binding Affinity and Interaction Mechanism of Chlorhexidine with Lysozyme: Insights from Surface Plasmon Resonance, Molecular Docking, and Molecular Dynamics Simulations. ChemistrySelect, 10(7), e202405476.

Sayğı, T. K., Pınar, E. G., Taştekil, I., Sarıca, P. Ö., Topçu, G., & Türkoğlu, E. A. (2025). Elucidation of the Binding Interaction between β‐Sitosterol and Lysozyme using Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance Analysis. Chemistry & Biodiversity, 22(2), e202401470.

Türkoğlu, E. A., Taştekil, I., & Özbek Sarica, P. (2024). Surface plasmon resonance, molecular docking, and molecular dynamics simulation studies of lysozyme interaction with tannic acid. Food Science & Nutrition, 12(10), 7392-7404.